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This model has three major advantages. Firstly, it closely resembles human type 1 diabetes with chronic pancreatic islet inflammation, insulitis, and insulin deficiency.
Secondly, the small size of mice makes it cost-effective to establish. Thirdly, a chemically-induced mouse model allows diabetes to be induced predictably and rapidly in a variety of different mouse strains allowing isogenic, allogenic or xenogenic transplantations to be carried out.
Besides diabetic mice models, STZ-induced rat model is also one of the earliest animal models of this condition, which is not used as commonly as the mouse model though.
Both type 1 and type 2 diabetic mice models can be obtained either through single high dose of STZ injection in adult rats or through immediate injection of STZ in neonatal rats.
Creative Biolabs provides various assessment options for testing the effectiveness of potential antidiabetic agents depending on your study objectives, including but not limited to:.
Additionally, Creative Biolabs also offers other types of rodent metabolic disease models that you may be interested in:. If you are interested in any of these models, please contact us or send us an inquiry.
We are willing to share our state-of-the-art platforms and sufficient expertise with our clients to boost their brilliant studies.
What is Streptozotocin STZ? Diabetes Mellitus and Animal Models Diabetes mellitus is a metabolic disease characterized by hyperglycemia that is caused by a relative or complete insulin deficiency.
Reference Wu, J. For a more pared-down menu and quirky USSR vibes, check out Central Congress , a sleek conference room-styled locale popular with Hamburg hipsters.
Competition for tickets is still fierce, but you can get a good sense of the building, and great harbour views, from the public viewing platform.
Say hello to one of Europe's largest red light districts. And where the seedy underbelly is, the best bars and clubs are sure to follow.
The lurid Reeperbahn aka 'The Kiez' sits in the middle, while surrounding it lies a swathe of fast food joints, sex shops, live music bars and strip joints.
The cheap and cheerful Pyjama Park Reeperbahn is about as close as you can get to the party strip, with bright and clean dorms and private rooms at superb value.
The more expensive East hotel brings hip design aesthetics to a former iron foundry, with an on-site spa and restaurant. Line your stomach with substantial Turkish mezze platters at Das Peace or a hearty plate of Knödel at cosy and candle-lit Marend.
Head to cult locale Zum Silbersack for a true neighbourhood Kneipe experience. This lush riverside suburb is one of the most affluent and desirable districts in Hamburg.
Situated on a hill to the west of the city centre, its winding streets boast a number of handsome villas, including the former residence of Karl Lagerfeld.
On the Elbchausee approaching Blankenese, the historic Hotel Louis C Jacob combines classic Hanseatic hospitality, outstanding comfort and Michelin-starred dining.
Breakfast is served in the chandeliered dining room with windows looking out towards Elbe. Its single, double and suite rooms are bright, peaceful and stylish, with luxurious toiletries and either a river or garden view.
With two Michelin stars and a lofty spot overlooking the Elbe, the Seven Seas is Hamburg dining at its finest and priciest.
For coffee, cake or tea-time elegance with a distinctly English charm and a much softer bill , try Luhmans Teestube. Beyond the elegant hotel bars, Blankenese is not a nightlife hotspot, but the relaxed Gastätte Linde has a hearty line of beers, as well as Glühwein and Grog for colder evenings.
Walk along the Strandpromenade towards the lighthouse, breathe in the fresh sea air and watch the ships go by.
Only in Hamburg can you take a stroll down the infamous Reeperbahn Red Light district, glimpse a miniature world on a gigantic scale and drink a gin basil smash at the bar that claims to have invented it.
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Time Out Hamburg. My Account My Profile Sign out. My Account. Worldwide icon-chevron-right Europe icon-chevron-right Germany icon-chevron-right Hamburg icon-chevron-right Where to stay in Hamburg.
Where to stay in Hamburg. DRINK With a waterfront location, live piano music and many the resident celebrity, the bar at the Hotel Atlantic Kempinksi is a popular point of cocktail pilgrimage, particularly for fans of German rock legend Udo Lindenberg who has lived in the hotel for decades.
If you do just one thing Check Prices. STAY A couple of minutes from the Sternschanze S-Bahn station by foot, Fritz in Pyjama is hip, colorful and comfortable, with individually decorated rooms and studios for a good, mid-range price.
DO Check out the Saturday Flohschanze flea market for vintage clothes, books, antiques and bargain bric-a-brac.
STAY Henri is a cool yet homey boutique hotel, channeling midcentury design, top-comfort furnishings and laid-back flair.
STAY The cheap and cheerful Pyjama Park Reeperbahn is about as close as you can get to the party strip, with bright and clean dorms and private rooms at superb value.
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Dance all night long — explore the bars and pubs of St. Pauli and Sternschanze. It's no surprise that Hamburg is dominated by the maritime industry.
Hamburg Invest supports companies looking to expand, restructure or invest in Hamburg. From the latest ship arrivals to hi-tech port logistics and a multitude of responsible bodies: we'll help you navigate Hamburg's port.
With the help of many innovative projects, Hamburg strives to become one of the leading cities in the field of smart mobility.
In a referendum, a scant majority of British voters chose to leave the EU. What effects does Brexit have on Hamburg?
Discover Hamburg's more than 30 Christmas markets and indulge in mulled wine, roasted chestnuts and an enchanting Winter atmosphere. Held three times a year, you can experience fun, nostalgia and thrills.
Think Germany, think Oktoberfest: with gigantic beers, brass bands and lederhosen. Hamburg, too, has its offshoot of this Bavarian event.
The annual Reeperbahn Festival in September is the perfect way to get an overview of St. Pauli's many live music venues. Every August, the rural heart of Northern Germany is swarming with heavy metal fans from all over the world.
See impressive cruise ships at Hamburg's port during this spectacular maritime Hamburg festival.
Every summer, around 50, bikers roll into the city for a weekend of gathering, live music and contests at the Harley Village.
At the Cyclassics, tens of thousands of pros and amateurs race through Hamburg's streets, port, and green environs.
Take part, or cheer on the With 10, athletes and , spectators, this triathlon is among the biggest and most prestigious events of its kind.
Whether short, queer, animated or documentary — Hamburg loves film and has the festivals to prove it. See what's on and enjoy the show.
Towering above the Elbe and HafenCity is the city's newest landmark — the impressive concert venue Elbphilharmonie Hamburg. Look no further than St.
Pauli's Landungsbrücken. Hamburg's parliament and senate assemble here. The famous street in the heart of St. Pauli offers everything from theatres and galleries to trendy nightclubs and smoky sailor bars.
The 'Michel' is Hamburg's largest church and one of the city's must-see sights. Its bell tower offers a stunning view over the city. Close Welcome to Hamburg.
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Dine and Drink Bars and Pubs. Network Hamburg Invest. Creative Biolabs offers CRO services with extensive expertise in conducting preclinical efficacy, proof-of-concept, and mechanism of action studies in various animal models of neurological diseases.
Our comprehensive battery of rodent neurological disease models is listed as follows:. Creative Biolabs works side-by-side with our clients in providing scientific guidance in the model selection, customized study design, end-point analysis, histopathology services, and assist you with professional interpretation of the data.
Contact us to discuss your specific needs if you are interested in our services. The generation of free radicals after ICV STZ injection is an important factor in causing cognitive impairment in rats.
Histological appearance of Ab and Tau neuropathology takes a long time to develop. Technical expertise is required for ICV infusion. Parameters that can be measured include, but are not limited to: Behavioral tests e.
Our comprehensive battery of rodent neurological disease models is listed as follows: Creative Biolabs works side-by-side with our clients in providing scientific guidance in the model selection, customized study design, end-point analysis, histopathology services, and assist you with professional interpretation of the data.
Reference Kosaraju, J. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease[J].
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